Anderson’s Disease: Affected Organelle in Protein Secretion

Subject : Biology

Question:

Anderson’s disease results in the failure to secrete large proteins called chylomicrons. Which organelle is most likely affected?

A. Vesicle

B. Lysosome

C. Mitochondrion

D. Nucleus

Expert Verified Solution:

The organelle most likely affected in Anderson’s disease is the vesicle. Chylomicrons are large lipoprotein particles involved in the transport of lipids from the intestines to other tissues. They are assembled in the cells of the intestinal lining and then secreted into the lymphatic system. This process relies on the proper functioning of vesicles, which are membrane-bound structures that transport proteins and lipids within the cell.

In Anderson’s disease, which is also known as Anderson’s congenital lipoprotein lipase deficiency, there is a defect in the secretion of these chylomicrons, indicating that the problem lies in the vesicles responsible for packaging and transporting these large proteins.